Plpro 3

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In addition to this proteolytic activity, PLpro reverses cellular ISGylation and ubiquitination processes, and may deubiquinate some host cell. A simple and high throughput method to identify human proteome substrates of SARS-CoV-2 viral proteases for further understanding of virus-host interactions. The SARS-CoV-2 papain-like protease (PLpro) is one of the two essential cysteine proteases involved in viral replication. While inhibitors of.